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Postdoctoral Research Fellow - Epigenomics/Bioinformatics
Cincinnati Children's Hospital Medical Center
Location: Cincinnati, Ohio
Academic / Research
Internal Number: 137430
A computational postdoctoral position in bioinformatics and epigenomics (computational/experimental) is available in Dr. Yaping Liu's lab in the Division of Human Genetics. One of the research directions in Dr. Liu's group is to study single-cell multi-omics data to understand the gene regulatory mechanism behind non-coding genetic variants. We have already developed several single-molecule (e.g. NOMe-seq, Kelly & Liu et al. 2012 Genome Research) and single-cell multi-omics technologies (e.g. single-cell Methyl-HiC, Li & Liu et al. 2019 Nature Methods). We are continuing to develop several novel multi-omics technologies ourselves (e.g. https://doi.org/10.1101/2022.03.29.486102), which have been supported by multiple internal and long-term NIH grants now. The new postdoctoral position is going to work on our own single-molecule and single-cell multi-omics technologies, integrate multi-omics signals from the same single cell, and finally understand the regulatory roles of non-coding genetics variants in the heterogenous cellular system.
MAJOR DUTIES AND RESPONSIBILITIES:
Provides expert-level knowledge in data characterization, annotation, quality assessment and discovery for various types of biomedical data (e.g., genomic, clinical, imaging, sequencing) in various formats (e.g., flat files, relational and non-relational databases).
Designs, develops, and evaluates scalable, searchable, and secure data structures, utilizing and expanding data standards.
Incorporates institutional resources and 3rd party software into specialized analysis workflows for the team and clients. Designs computational infrastructures to controls the flow of data and information for studies.
Maintains expertise in public and proprietary bioinformatics tools. Contributes to the development of data and analytical standards and operating procedures based on scientific literature and best practices.
Present research at laboratory meetings, journal clubs, seminars, and meetings.
Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
Maintain currency in field through continuing education, literature, and seminars.
Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures.
Perform other duties as assigned.
Cincinnati Children's Research and Training at a Glance
Among the top in NIH funding for pediatric research institutions
Over 1.4 million square feet of research laboratory space
900+ scientists conducting basic, translational, and clinical research
Over 2000 publications annually in top-tier journals
Access to Employee Resource Groups and Mentorship programs
Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
Ph.D. in related discipline, MD, or equivalent degree
PhD in Computer Science, Physics, Biomedical Informatics, Bioinformatics, Epidemiology, Biostatistics or other similar quantitative disciplines
Experience in a related disipline
The ideal candidate will have a recent PhD and 3+ years of experience, in computational biology, bioinformatics, genomics or quantitative research fields, proficiency with at least one high-level scripting language (R or Python) and Linux operating system (Bash), excellent quantitative background in statistics and machine learning, and/or computational genomics background, at least one impactful first or co-first author SCI paper published or accepted, and must be an effective communicator (spoken and written). Familiarity with large-scale next-generation sequencing (NGS) data analysis (WGS, WGBS, RNA-seq, ATAC-seq and/or related) and/or single-cell multi-omics preferred.
REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Outstanding computer literacy and in-depth knowledge of software applications. Analytical ability sufficient to perform complex data comparisons; mathematical ability sufficient to perform complex algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
Cincinnati Children's is proud to be an Equal Opportunity Employer that values and treasures Diversity, Equity, and Inclusion. We are committed to creating an environment of dignity and respect for all our employees, patients, and families (EEO/AA).
About Cincinnati Children's Hospital Medical Center
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.